Mindfulness-based cognitive therapy v. treatment as usual in people with bipolar disorder: A multicentre, randomised controlled trial

Description

The purpose of this multicentre, evaluator blinded RCT was to investigate the added value of MBCT to treatment as usual (TAU) in BD up to 15 months follow-up (NCT03507647). A total of 144 participants with BD type I and II were randomised to MBCT + TAU (n = 72) and TAU (n = 72). Primary outcome was current depressive symptoms. Secondary outcomes were current (hypo)manic and anxiety symptoms, recurrence rates, rumination, dampening of positive affect, functional impairment, mindfulness skills, self-compassion, and positive mental health.

Principal Investigator

Imke Hanssen

Other Collaborators

Marloes Huijbers, Eline Regeer, Marc Lochmann van Bennekom, Anja Stevens, Petra van Dijk, Elvira Boere, Rob Havermans, Rogier Hoenders, Ralph Kupka, Anne E Speckens

Publication Details

Study Info

  • Study Design: RCT,
  • Population Type: Clinical, Bipolar disorder
  • Age Group: Adults (25-65)
  • Control Group: Passive control group
  • Total Sample Size: 144

Intervention Info

  • Intervention Type: MBCT
  • Intervention Details: A randomized, multicenter, prospective, evaluator-blinded clinical trial of MBCT added to treatment as usual (TAU) versus TAU alone. Assessments will be conducted at baseline and at 3, 6, 9, 12 and 15 months follow-up. The MBCT treatment will based on the 8-week MBCT course developed by Segal, Williams and Teasdale (2012), but will be adapted to address the needs of patients with a bipolar disorder. A few examples of these adaptations are: (more) psychoeducation about manic symptoms in addition to the psychoeducation about depression; introducing the 3-minute breathing space earlier in the programme and more often during sessions, especially when strong emotions are present; repeatedly bringing the focus to self-care; and making use of the mindful movement (yoga) exercises more frequently. All group sessions will be conducted at the respective mental health centres, with each group comprising 8-12 participants. MBCT courses will be taught by experienced and qualified mindfulness teachers, together with a health care professional specialised in the care for BD patients. Teacher competency will be assessed with the Mindfulness-Based Interventions - Teaching Assessment Criteria (Crane et al 2013), for which all trial sessions will be videotaped.
  • Intervention Length: 8
  • Questionnaires: State-Trait Anxiety Inventory-I (STAI), Ruminative Response Scale (RRS), Five-Facet Mindfulness Questionnaire (FFMQ), Self-compassion Scale (SCS), Inventory of Depressive Symptomatology – Clinician administered (IDS-C), Young Mania Rating Scale (YMRS), Functioning Assessment Short Test (FAST), Mental Health Continuum – Short Form (MHC-SF)

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